transcriptional control

transcriptional control
Control of gene expression by controlling the number of RNA transcripts of a region of DNA. A major regulatory mechanism for differential control of protein synthesis in both pro- and eukaryotic cells.

Dictionary of molecular biology. 2004.

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  • Control (genetic) — The control of gene expression. Genetic control may be on the transcriptional or translational level. Transcriptional control works by controlling the number of RNA transcripts of a region of DNA, indirectly controlling protein synthesis.… …   Medical dictionary

  • transcriptional silencing — Mechanism of transcriptional control where DNA is bundled into heterochromatin in order to make it permanently inaccessible for future transcription. Effectively, this allows for memory in the determination of cell fate in developing organisms.… …   Dictionary of molecular biology

  • Transcriptional regulation — is the change in gene expression levels by altering transcription rates. Regulation of transcriptionRegulation of transcription controls when transcription occurs and how much RNA is created. Transcription of a gene by RNA polymerase can be… …   Wikipedia

  • transcriptional roadblock — A DNA binding protein which affects the rate at which RNA polymerases transcribe genes. The protein/DNA complex interferes with the passage of the elongation complex. In some cases these obstacles are readily bypassed, but in others a significant …   Glossary of Biotechnology

  • locus control region — (= control region; LCR) Region of DNA which contains the promoters and enhancers that regulate the expression of a particular gene. Often taken to be a single region 0 2kb upstream of the transcriptional start site, although there are probably… …   Dictionary of molecular biology

  • Post-transcriptional regulation — is the control of protein synthesis by genes after synthesis of RNA has begun.cite book | author = Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter | title = Molecular Biology of the Cell | publisher =… …   Wikipedia

  • Post-transcriptional modification — is a process in cell biology by which, in eukaryotic cells, primary transcript RNA is converted into mature RNA. A notable example is the conversion of precursor messenger RNA into mature messenger RNA (mRNA), which includes splicing and occurs… …   Wikipedia

  • Tetracycline controlled transcriptional activation — is a method of inducible expression where transcription is reversibly turned on or off in the presence of the antibiotic tetracycline or one of its derivatives (etc. doxycycline). In nature, pTet promotes TetR, the repressor, and TetA, the… …   Wikipedia

  • Locus control region — Locus control regions (LCR) are defined by their ability to enhance the expression of linked genes to physiological levels in a tissue specific and copy number dependent manner at ectopic chromatin sites. The concept that developmental and cell… …   Wikipedia

  • locus control region — (LCR) a segment of DNA situated apart from a structural gene or cluster of genes but acting in cis to increase the transcriptional activity of the gene or cluster, probably by opening and remodeling chromatin structure …   Medical dictionary

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